Here we report the results of a genetic characterisation of retinal vasculature. Measurements of ocular parameters may therefore offer important information on the physiology and homeostasis of these two important systems. It is also a window through which elements of the cardiovascular and nervous systems can be directly inspected, using ophthalmoscopy or retinal imaging. The eye is the window through which light is transmitted and visual sensory signalling originates. Comparison of part associations observed for the traits of interest with additional covariates (age2, smoking, diabetes). Replication of GWAS results in a recent publication (Zekavat BS et al., 2021). Mendelian randomisation analyses testing causality of metabolic traits over vascular changes. Mendelian randomisation analyses testing causality of vascular changes over metabolic traits. Table I: Ldsc genetic correlation between retinal parameters and systemic traits and disease.

Functional analyses of causation for SNPs associated with AT. eQTL effects of SNPs associated in the GWAS. Known loci replicated in trans-ancestry analysis combining Asian, African and European analysis.

Results of the meta-analyses of the UK Biobank and EPIC-Norfolk cohorts. Replication of GWAS results in the EPIC-Norfolk cohort. Most significant associations observed for the traits of interest. Table B: Genetic intercorrelations between the four retinal vasculature parameters. Strachan, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing,Īnd The UK Biobank Eye and Vision Consortium

Owen, Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing, Rudnicka, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing,Ĭhristopher G. Whincup, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – review & editing,Īlicja R. Barman, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing, Welikala, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing, Foster, Data curation, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing, Hammond, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing, Zihe Xu, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing,Ĭhristopher J. Mahroo, Investigation, Methodology, Validation, Visualization, Writing – review & editing, Khawaja, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing, Hysi, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing,Īnthony P. Xiaofan Jiang, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing,

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